Research explores relationship between fever and cancer occurrence

<p>Washington D.C. [USA] Aug 19 (ANI): In a new study, scientists have explored the relationship between fever and cancer incidence.</p><p>The recurring patterns in patient accounts suggest the existence of an inverse relationship between the history of infectious fever and cancer risk which are documented throughout decades of medical literature.</p><p>However, evidence supporting this correlation continues to be primarily anecdotal.</p><p>Drawing upon previous research and experimental data, the authors argue that repeated exposure to fever enhances the ability of gd T cells to detect cellular abnormalities and to foster inhospitable environments that destroy malignant cells.</p><p>This paper is the first to acknowledge the role that gd T cells may play as participants in this inverse relationship.</p><p>Infectious fever is the defensive and adaptive reaction that occurs when an organism\'s immune system comes into contact with exogenous pyrogens, or pathogen-associated molecular pattern (PAMP). Upon recognition of these exogenous pyrogens, endogenous mediators--also known as endogenous pyrogens--engage the febrile system.</p><p>The authors further elaborate on the function of endogenous mediators, like cytokines.</p><p>\"In short, endogenous mediators of fever redirect metabolic substrates and energy to the immune system during fever. This markedly enhances the frequency of a vast range of immune effectors, including lymphocytes expressing gd heterodimer receptors, which possess a potent anti-infectious and antitumor competence,\" wrote authors.</p><p>Exposure to infection significantly expands the quantity of gd T cells. During infection, blood Vg9Vd2 T cells can increase in number until they constitute 60 percent of the total amount of lymphocytes.</p><p>While previous research and current cancer immunotherapy practices predominately focus on alpha/beta (ab) T cells, analysis of the interaction between fever and gd T cells may generate further inquiry into the larger impact and the clinical benefits of this relationship.</p><p>The full findings appeared in the journal- Quarterly Review of Biology. (ANI)</p><br/><center><em><p>This story has not been edited. It has been published as provided by ANI</p></em></center>

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